منابع مشابه
Quantification of calcification in atherosclerotic lesions.
Calcification can be deposited throughout the vasculature in several forms of calcium phosphate, including calcium hydroxyapatite (CHA). Calcium accumulation in arteries by mineralization and calcium loss from bone by osteoporosis often coexist, and vascular calcification may share common mechanisms with bone remodeling. Deposition of calcification in valves and arteries diminishes the valvular...
متن کاملNanoscale architecture in atherosclerotic calcification.
Calcium mineral deposits are radiographically evident in the majority of significant atherosclerotic lesions.1 These deposits generally consist of a nonhomogeneous composite containing hydroxyapatite mineral nanocrystals embedded in an organic matrix including type I collagen nanofibers. The morphometry varies over a spectrum. Amorphous deposits lack organization at the lightmicroscopic scale, ...
متن کاملAtherosclerotic Lesions
Oxidatively modified lipoproteins have been implicated in atherogenesis, but the mechanisms that promote oxidation in vivo have not been identified. Myeloperoxidase, a heme protein secreted by activated macrophages, generates reactive intermediates that oxidize lipoproteins in vitro. To explore the potential role of myeloperoxidase in the development of atherosclerosis, we determined whether th...
متن کاملLupin protein isolate and cysteine-supplemented casein reduce calcification of atherosclerotic lesions in apoE-deficient mice.
Protein from lupin is supposed to have anti-atherogenic effects due to its lipid-lowering properties in laboratory animals. It is further suggested that the amino acid cysteine plays a crucial role in this aspect. The objective of the present study was to compare the effects of lupin protein and cysteine-supplemented casein with those of casein on atherosclerotic lesion development in apoE-defi...
متن کاملDecorin promotes aortic smooth muscle cell calcification and colocalizes to calcified regions in human atherosclerotic lesions.
OBJECTIVE Ectopic calcification localized to the intima of atherosclerotic plaque is a risk marker for cardiovascular events and increases the risk of aortic dissection during angioplasty. A variety of extracellular matrix molecules such as collagen type 1, bone sialoprotein, and osteopontin are known to regulate the biomineralization of bone and ectopic vascular calcification. In the present s...
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ژورنال
عنوان ژورنال: Current Opinion in Lipidology
سال: 2016
ISSN: 0957-9672
DOI: 10.1097/mol.0000000000000344